Multi-Omics insights into the molecular mechanisms of trochlear dysplasia: A proteomic and metabolomic study in rats
This study integrates proteomic and metabolomic analyses to uncover molecular alterations in a rat model of TD. Significant findings include upregulation of Col3a1 and altered metabolites such as creatine and L-malic acid. These results highlight the role of metabolic disturbances such as glycine, serine, and threonine metabolism and the PI3K-Akt signaling pathway in TD pathology. The study provides valuable biomarkers and insights into the mechanisms of TD, offering potential targets for future therapeutic and diagnostic strategies.
Authors
- Chongyi Fan
- Yingzhen Niu (ORCID: https://orcid.org/0000-0003-0058-7254)
- Kuo Hao (ORCID: https://orcid.org/0000-0002-6172-8738)
- Huijun Kang
- Fei Wang (ORCID: https://orcid.org/0000-0002-0461-155X)
- Y. Li (ORCID: https://orcid.org/0009-0003-5197-9482)
- P. Liu
- Zhenhui Huo
- Fei Wang
Institutions
- Hebei Medical University (CN)
- Hebei University of Technology (CN)
- Third Hospital of Hebei Medical University (CN)
- Cangzhou Central Hospital (CN)
- Aerospace Center Hospital (CN)
- People's Hospital of Cangzhou (CN)
- Hebei University (CN)
Publication Details
- Journal
- PLoS ONE
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1371/journal.pone.0325562
- Primary Topic
- Lower Extremity Biomechanics and Pathologies
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China