Modification of the Cardiac Renal Angina Index for Predicting Adverse Kidney Events After Pediatric Cardiac Surgery
The cRAI demonstrates strong predictive performance for adverse renal outcomes. Patients who were cRAI positive had worse outcomes, while the composite outcome was effectively ruled out in patients who were cRAI negative. Urine neutrophil gelatinase-associated lipocalin integration improved predictive performance parameters. cRAI holds potential for cardiac surgery-associated acute kidney injury risk stratification to enrich clinical trial enrollment.
Authors
- Huaiyu Zang (ORCID: https://orcid.org/0000-0001-8550-3827)
- Stuart L. Goldstein (ORCID: https://orcid.org/0000-0003-3711-8785)
- Megan SooHoo (ORCID: https://orcid.org/0000-0002-5513-2022)
- Shina Menon (ORCID: https://orcid.org/0000-0001-8473-0307)
- Rajit K. Basu (ORCID: https://orcid.org/0000-0002-3184-341X)
- Katherine Melink
- Katja M. Gist (ORCID: https://orcid.org/0000-0002-7427-670X)
- Kevin A. Pettit (ORCID: https://orcid.org/0000-0001-9385-0220)
- Nicholas J. Ollberding (ORCID: https://orcid.org/0000-0001-9404-7368)
- Natalja L. Stanski (ORCID: https://orcid.org/0000-0003-4473-8376)
- Jeffrey A. Alten (ORCID: https://orcid.org/0000-0001-6572-3777)
- Emily Gorrell
Institutions
- Cincinnati Children's Hospital Medical Center (US)
- Boston Children's Hospital (US)
- Lucile Packard Children's Hospital (US)
- Harvard University (US)
- Children's Hospital Colorado (US)
- Lurie Children's Hospital (US)
- University of Colorado Anschutz Medical Campus (US)
- University of Cincinnati Medical Center (US)
- University of Colorado Denver (US)
- Stanford University (US)
Publication Details
- Journal
- Journal of the American Heart Association
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1161/jaha.125.042941
- Citations
- 3
- Primary Topic
- Hemodynamic Monitoring and Therapy
- Type
- article
- Field-Weighted Citation Impact
- 6.02