Standardised TruAI Automated Quantification of Intracellular Neuromelanin Granules in Human Brain Tissue Sections
The TruAI automated platform reliably quantifies individual neuromelanin granules in catecholamine neurons. Extraneuronal pigments are considerably smaller in size than intracellular neuromelanin, and intracellular neuromelanin changes its properties with age. The darkening and colour change of intracellular neuromelanin suggest an increase in eumelanin over time in healthy individuals. These changes can be reliably identified using the automated platform.
Authors
- Anastasia Filimontseva (ORCID: https://orcid.org/0000-0002-3316-9035)
- YuHong Fu (ORCID: https://orcid.org/0000-0003-4539-2039)
- Zac Chatterton (ORCID: https://orcid.org/0000-0002-6683-1400)
- Glenda Margaret Halliday (ORCID: https://orcid.org/0000-0003-0422-8398)
- Miquel Vila (ORCID: https://orcid.org/0000-0002-1352-989X)
- Joan Compte (ORCID: https://orcid.org/0000-0001-5447-5122)
- Amy Burke (ORCID: https://orcid.org/0009-0006-9274-9589)
- Thais Cuadros (ORCID: https://orcid.org/0000-0001-7376-7470)
- Anahid Ansari Mahabadian (ORCID: https://orcid.org/0009-0000-0088-0544)
Institutions
- Institució Catalana de Recerca i Estudis Avançats (ES)
- Universitat Autònoma de Barcelona (ES)
- The University of Sydney (AU)
- Biomedical Research Networking Center on Neurodegenerative Diseases (ES)
- Vall d'Hebron Institut de Recerca (ES)
- Research Network (United States) (US)
Publication Details
- Journal
- Neuropathology and Applied Neurobiology
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1111/nan.70033
- Citations
- 1
- Primary Topic
- melanin and skin pigmentation
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Michael J. Fox Foundation for Parkinson's Research
- Aligning Science Across Parkinson’s
- Medical Research Council
- National Health and Medical Research Council