Hippocampal Avoidance During Prophylactic Cranial Irradiation for Patients With Small Cell Lung Cancer: Randomized Phase II/III Trial NRG-CC003
Although the study did not meet its primary end point of DR preservation, HA during PCI reduces the risk of overall neurocognitive toxicity with noninferior ICR risk and similar survival.
Authors
- Kristin J. Redmond (ORCID: https://orcid.org/0000-0003-3442-4613)
- Harold Yoon
- Benjamin H. Lok (ORCID: https://orcid.org/0000-0002-3675-8847)
- André Konski (ORCID: https://orcid.org/0000-0002-6936-7682)
- Kiran Devisetty (ORCID: https://orcid.org/0000-0001-9762-6621)
- Vinai Gondi
- Edward C. McCarron (ORCID: https://orcid.org/0009-0007-3640-3214)
- Abraham J. Wu (ORCID: https://orcid.org/0000-0002-2597-7091)
- Shannon Fogh
- J.C. Grecula (ORCID: https://orcid.org/0009-0007-1817-063X)
- Wolfgang A. Tomé (ORCID: https://orcid.org/0000-0003-1586-8091)
- J.H. Heinzerling
- A. Sun (ORCID: https://orcid.org/0000-0002-7790-373X)
- Minesh P. Mehta (ORCID: https://orcid.org/0000-0002-4812-5713)
- Edmund L. Simon
- Samir Narayan
- Gregory M.M. Videtic (ORCID: https://orcid.org/0000-0002-6276-1505)
- Joseph Bovi (ORCID: https://orcid.org/0000-0002-3686-1940)
- Rebecca Paulus (ORCID: https://orcid.org/0000-0001-7312-1194)
- Isabelle Thibault (ORCID: https://orcid.org/0000-0002-2161-2124)
- Benjamin W. Corn (ORCID: https://orcid.org/0000-0002-2881-0326)
- Vijayananda Kundapur (ORCID: https://orcid.org/0000-0002-2402-2154)
- Lisa A. Kachnic (ORCID: https://orcid.org/0000-0001-8239-9147)
- Jeffrey S. Wefel (ORCID: https://orcid.org/0000-0002-3817-2479)
- Clifford G. Robinson (ORCID: https://orcid.org/0000-0002-1399-9904)
- Laurie E. Gaspar
- Albert S. DeNittis
- Ronald C. McGarry
- Jondavid Pollock
- Stephanie L. Pugh (ORCID: https://orcid.org/0000-0002-5977-8912)
Institutions
- American College of Radiology (US)
- Northwestern University (US)
- Albert Einstein College of Medicine (US)
- Cleveland Clinic (US)
- University Health Network (CA)
- Memorial Sloan Kettering Cancer Center (US)
- Montefiore Medical Center (US)
- The University of Texas MD Anderson Cancer Center (US)
- University of Kentucky (US)
- Johns Hopkins University (US)
- Wheeling Jesuit University (US)
- Wayne State University (US)
- Washington University in St. Louis (US)
- MedStar Franklin Square Medical Center (US)
- Columbia University Irving Medical Center (US)
- Forsyth County Schools (US)
- Johns Hopkins Medicine (US)
- West Virginia Northern Community College (US)
- Shaare Zedek Medical Center (IL)
- Lankenau Medical Center (US)
- Princess Margaret Cancer Centre (CA)
- Chester County Hospital (US)
- The Barbara Ann Karmanos Cancer Institute (US)
- Levine Cancer Institute (US)
- University of Wisconsin Carbone Cancer Center (US)
- ThedaCare (US)
- University of California San Francisco Medical Center (US)
- Heartland Cancer Research (US)
- Michigan Cancer Research Consortium (US)
- Wheeling Hospital (US)
- Miami Heart Research Institute (US)
- NRG Oncology (US)
- Université Laval (CA)
- The Ohio State University (US)
- University of Colorado Denver (US)
Publication Details
- Journal
- Journal of Clinical Oncology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1200/jco-25-00221
- Citations
- 6
- Primary Topic
- Brain Metastases and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 9.11