Associations of leucocyte subtypes and platelet parameters with kidney cancer risk in the UK Biobank cohort
Our findings support two separate longer-acting pathways in kidney cancer development- a pathway related to general rather than abdominal obesity and an immune-cell-related pathway involving neutrophils assisted by activated platelets, as well as a cancer-induced thrombo-inflammation closer to kidney cancer diagnosis.
Authors
- Sofia Christakoudi (ORCID: https://orcid.org/0000-0001-9219-4436)
- Elio Ríboli (ORCID: https://orcid.org/0000-0001-6795-6080)
- Marc J. Gunter (ORCID: https://orcid.org/0000-0001-5472-6761)
- Konstantinos K Tsilidis
Institutions
- University of Ioannina (GR)
- Imperial College London (GB)
Publication Details
- Journal
- Journal of Inflammation
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s12950-025-00458-6
- Primary Topic
- Inflammatory Biomarkers in Disease Prognosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Institute for Health and Care Research
- Imperial College London
- NIHR Imperial Biomedical Research Centre