Promoting mitochondrial fusion is protective against cancer-induced muscle detriments in males and females
Promoting mitochondrial fusion via OPA1 induction improved cachectic outcomes in mice. Targeting OPA1providing provides a promising therapeutic approach for CC treatment.
Authors
- Nicholas P. Greene (ORCID: https://orcid.org/0000-0001-9621-2005)
- Dipak Kumar Mishra (ORCID: https://orcid.org/0000-0002-1652-2685)
- Eleanor Schrems
- Tyrone A. Washington (ORCID: https://orcid.org/0000-0002-1919-5907)
- Pieter J Koopmans
- Kevin A. Murach (ORCID: https://orcid.org/0000-0003-2783-7137)
- Toby L. Chambers (ORCID: https://orcid.org/0000-0001-7567-1819)
- Ana Regina Cabrera (ORCID: https://orcid.org/0000-0002-9811-3585)
- Francielly Morena da Silva (ORCID: https://orcid.org/0000-0001-5019-2125)
- Stavroula Tsitkanou (ORCID: https://orcid.org/0000-0002-6753-5945)
- Sepideh Shakeri (ORCID: https://orcid.org/0000-0002-8333-8570)
- Sabin Khadgi (ORCID: https://orcid.org/0009-0002-8394-624X)
- Seongkyun Lim (ORCID: https://orcid.org/0000-0001-7075-5909)
- Kevin Zhao (ORCID: https://orcid.org/0009-0004-4573-9412)
- Calvin Peterson
- Ruqaiza Muhyudin
Institutions
- University of Arkansas at Fayetteville (US)
Publication Details
- Journal
- BMC Cancer
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s12885-025-14630-x
- Citations
- 3
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 2.42
Funders
- National Institutes of Health
- National Institute of General Medical Sciences
- National Institute of Arthritis and Musculoskeletal and Skin Diseases