Barcoded Orthotopic Patient‐Derived Head & Neck Squamous Cell Carcinoma Model Demonstrating Clonal Stability and Maintenance of Cancer Driver Mutational Landscape
Our study presents a barcoded orthotopic patient-derived xenograft model for head and neck squamous cell carcinoma with clonal stability. This model provides a way to study phenotypic effects of single cell level gene manipulation in a pooled format. The method can be adapted for in vitro work as well.
Authors
- Peiran Zhou (ORCID: https://orcid.org/0000-0003-4104-5873)
- Brittany Barber
- Caroline Mills (ORCID: https://orcid.org/0000-0001-8887-6282)
- Slobodan Beronja (ORCID: https://orcid.org/0000-0002-6769-9261)
- Zhao Dong (ORCID: https://orcid.org/0000-0002-6188-1337)
Institutions
- University of Washington (US)
- Fred Hutch Cancer Center (US)
- VA Puget Sound Health Care System (US)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/cam4.71137
- Primary Topic
- Cancer Genomics and Diagnostics
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fred Hutchinson Cancer Research Center
- University of Washington