Mitochondrial function is impaired in long COVID patients
PBMCs from Long COVID subjects exhibit an exceptional and distinctive change in ATP synthase, as it contributes to the mitochondrial membrane potential rather than using it exclusively to generate ATP. The findings suggest that the enzyme runs both forward and reverse reactions, synthesising and hydrolysing ATP. The correlation of mitochondrial function with clinical phenotype in Long COVID may indicate a causal relationship and warrants further validation in larger scale studies.
Authors
- Jane Macnaughtan (ORCID: https://orcid.org/0000-0003-1211-9298)
- Antonella Spinazzola (ORCID: https://orcid.org/0000-0003-4242-8091)
- Melissa Heightman (ORCID: https://orcid.org/0000-0002-7507-2119)
- Marco Toffoli (ORCID: https://orcid.org/0000-0002-3255-9648)
- Kai‐Yin Chau (ORCID: https://orcid.org/0000-0002-5797-2922)
- Anthony H.V. Schapira (ORCID: https://orcid.org/0000-0002-3018-3966)
- Toby Hillman (ORCID: https://orcid.org/0000-0002-3711-3960)
- Ewen Brennan (ORCID: https://orcid.org/0000-0003-2132-5157)
Institutions
- University College London Hospitals NHS Foundation Trust (GB)
- Foundation for Liver Research (GB)
- Institute for Liver Health (US)
- National Hospital for Neurology and Neurosurgery (GB)
- University College London (GB)
Publication Details
- Journal
- Annals of Medicine
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1080/07853890.2025.2528167
- Citations
- 4
- Primary Topic
- Mitochondrial Function and Pathology
- Type
- article
- Field-Weighted Citation Impact
- 3.22