Tumor-microenvironment triggered Mn-Gd based nanosystem for breast carcinoma suppression via synergistic radiotherapy and glutathione-depleting along with glucose oxidase combination enhanced Ros storm
Remarkably, the VMn-Gd@GOx-EVs platform effectively induces cell death in breast carcinoma models both in vitro and in vivo by harnessing the combined effects of RT and reactive oxygen species (ROS) generated by Mn ion catalysis under X-ray irradiation. Moreover, with its magnetic resonance imaging capabilities, this multi-functional diagnostic and therapeutic platform shows significant potential for clinical tumor treatment.
Authors
- Dongqun Guo
- Zongjunlin Liu
- Jianqiao Zhong (ORCID: https://orcid.org/0000-0002-0482-1215)
- Yinghao Liang
- Xiqian Chen (ORCID: https://orcid.org/0000-0001-6953-4957)
- Yonghui Su (ORCID: https://orcid.org/0000-0002-7959-6892)
- Yan Huang (ORCID: https://orcid.org/0000-0001-5466-7714)
- Qian Tang (ORCID: https://orcid.org/0000-0002-7759-2476)
- Siyu Chen (ORCID: https://orcid.org/0000-0003-1156-7910)
- Tuerdimaimaiti Meiheriban
Institutions
- Fujian Medical University (CN)
- Affiliated Hospital of Southwest Medical University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Suizhou Central Hospital (CN)
- Second Affiliated Hospital of Fujian Medical University (CN)
Publication Details
- Journal
- Journal of Nanobiotechnology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s12951-025-03636-z
- Citations
- 1
- Primary Topic
- Nanoplatforms for cancer theranostics
- Type
- article
- Field-Weighted Citation Impact
- 0.67
Funders
- National Science Foundation
- Southwest Medical University