Low-liver-accumulation lipid nanoparticles enhance the efficacy and safety of HPV therapeutic tumor vaccines
By employing a novel, non-patented ionizable lipid design, this work balances delivery efficiency and biosafety, Lipid 7 offers a high-efficacy, low-toxicity therapeutic strategy for HPV-related cancers.
Authors
- Yan Sun (ORCID: https://orcid.org/0000-0002-6616-8784)
- Xueli Bai (ORCID: https://orcid.org/0000-0002-2934-0880)
- Chuanxin Guo
- Shuyan Yang (ORCID: https://orcid.org/0000-0003-0806-2487)
- Zhidan Tian (ORCID: https://orcid.org/0009-0008-8888-9188)
- Xiaowei Cai (ORCID: https://orcid.org/0009-0000-0939-0090)
- Tao Liu (ORCID: https://orcid.org/0000-0001-7455-8240)
- Meng Wang (ORCID: https://orcid.org/0000-0002-4970-8590)
- Pei Wang (ORCID: https://orcid.org/0000-0002-6890-6453)
- Yuan Fang (ORCID: https://orcid.org/0009-0008-1520-5494)
- J Zeng (ORCID: https://orcid.org/0009-0002-5249-6311)
- Qijun Qian (ORCID: https://orcid.org/0009-0008-6949-3866)
- Xiaodie Wang
Institutions
- Shanghai University (CN)
- Shanghai Jian Qiao University (CN)
- Shanghai Cell Therapy Research Institute (CN)
Publication Details
- Journal
- Journal of Translational Medicine
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s12967-025-06924-2
- Citations
- 4
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 3.19