DGKζ in Glycerophospholipid Metabolism Regulates the DAG and PA Balance and Interacts With PTEN to Alleviate Brain Damage in Septic Mice With Hydrogen Inhalation: A Comparative Metabolomic and Phosphoproteomic Analysis
H<sub>2</sub> downregulates the levels of DGKζ and CCTα to alleviate brain damage in septic mice, and changes in DGKζ expression are balancing the transformation between the DAG anf PA, and it might also interact with PTEN. Thus, DGKζ may be a potential target in septic mouse therapy.
Authors
- Yonghao Yu (ORCID: https://orcid.org/0000-0001-7989-805X)
- Yi Jiang (ORCID: https://orcid.org/0000-0001-5114-0183)
- Yuanyuan Bai (ORCID: https://orcid.org/0000-0002-4059-6334)
- Beibei Dong (ORCID: https://orcid.org/0000-0002-9711-2353)
- Zeyu Li (ORCID: https://orcid.org/0000-0001-9568-3315)
- Yan Dong-lai
Institutions
- Tianjin Medical University General Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/brb3.70761
- Citations
- 2
- Primary Topic
- Hydrogen's biological and therapeutic effects
- Type
- article
- Field-Weighted Citation Impact
- 4.01
Funders
- National Natural Science Foundation of China
- Tianjin Science and Technology Program