Rethinking Radiation Therapy for Perineural Invasion in Oral Cancer: Does More Coverage Improve Outcomes?
Our findings suggest that expanding RT volumes to cover entire cranial nerve pathways may not improve outcomes and increase the risk of toxicity. A personalised approach to RT planning, incorporating PNI extent, nerve involvement and other high-risk features, is essential for optimising treatment outcomes in PNI-positive OSCC.
Authors
- Anuj Kumar (ORCID: https://orcid.org/0000-0001-9660-1510)
- Anuja Deshmukh
- Swapnil Ulhas Rane (ORCID: https://orcid.org/0000-0002-5374-3903)
- Chandrashekhar Dravid
- Poonam Joshi (ORCID: https://orcid.org/0000-0002-7016-8437)
- Vidisha Tuljapurkar (ORCID: https://orcid.org/0000-0002-0928-1908)
- Monali Swain (ORCID: https://orcid.org/0000-0002-8111-4127)
- Arjun Singh (ORCID: https://orcid.org/0000-0002-8119-8439)
- Shwetabh Sinha (ORCID: https://orcid.org/0000-0003-3369-3870)
- Sarbani Ghosh Laskar (ORCID: https://orcid.org/0000-0003-0744-4838)
- Pallavi Rane (ORCID: https://orcid.org/0000-0002-5149-7323)
- Pankaj Chaturvedi (ORCID: https://orcid.org/0000-0002-3520-1342)
- Rathan Shetty
- Samarpita Mohanty (ORCID: https://orcid.org/0000-0002-8037-957X)
- Munita Bal (ORCID: https://orcid.org/0000-0002-0345-5620)
- Shivakumar Thiagarajan (ORCID: https://orcid.org/0000-0003-1957-3338)
- Gouri Pantvaidya
- Sudhir Vasudevan Nair (ORCID: https://orcid.org/0000-0003-4977-3779)
- Asawari J. Patil (ORCID: https://orcid.org/0000-0002-8203-986X)
- Neha Mittal (ORCID: https://orcid.org/0000-0003-1755-2437)
- Ashwini Budrukkar (ORCID: https://orcid.org/0000-0002-6019-7859)
- Richa Vaish
- Ashwini Adhau
Institutions
- Homi Bhabha National Institute (IN)
- Tata Memorial Hospital (IN)
Publication Details
- Journal
- Cancer Medicine
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/cam4.71134
- Citations
- 3
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.54
Funders
- Tata Memorial Centre