Clinical characteristics and efficacy of short-course antibiotic therapy for <i>Staphylococcus aureus</i> bacteremia in hematological patients
There is still no consensus on the optimal antibiotic course for <i>Staphylococcus aureus</i> bacteremia (SAB) in patients with hematological diseases. Some studies have suggested that short-course antibiotic therapy was feasible for uncomplicated SAB, but few have targeted hematological patients. Here, we described clinical characteristics and outcomes of SAB in hematological patients and highlighted advanced age, refractory or relapsed hematological diseases, and polymicrobial infection as independent predictors of 90-day mortality, while MRSA bacteremia was associated with early mortality risk. And we demonstrated that short-course antibiotic therapy (≤10 days) for uncomplicated SAB in hematological patients was non-inferior to long-course one (>10 days).
Authors
- Zhijian Xiao (ORCID: https://orcid.org/0000-0001-8008-7385)
- BeiJun Chen (ORCID: https://orcid.org/0000-0003-3777-7609)
- Yingchang Mi (ORCID: https://orcid.org/0000-0002-5060-5070)
- Qingsong Lin (ORCID: https://orcid.org/0000-0001-6082-8684)
- Hui Wang (ORCID: https://orcid.org/0000-0001-9220-0357)
- Erlie Jiang (ORCID: https://orcid.org/0000-0003-0237-6063)
- Sizhou Feng (ORCID: https://orcid.org/0000-0003-2768-6690)
- Fengkui Zhang (ORCID: https://orcid.org/0000-0002-2797-1339)
- Jianxiang Wang (ORCID: https://orcid.org/0000-0001-9437-9151)
- Xiaomeng Feng
- Mingzhe Han
- Yizhou Zheng (ORCID: https://orcid.org/0000-0001-5939-7549)
- Nuobing Yang
- Lugui Qiu (ORCID: https://orcid.org/0000-0002-9948-1662)
Institutions
- Qingdao University (CN)
- Fujian Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Yuhuangding Hospital (CN)
- National Clinical Research (US)
- Fujian Provincial Hospital (CN)
- Institute of Hematology & Blood Diseases Hospital (CN)
Publication Details
- Journal
- Microbiology Spectrum
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1128/spectrum.02325-24
- Citations
- 1
- Primary Topic
- Neutropenia and Cancer Infections
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- National Natural Science Foundation of China
- National Key Research and Development Program of China