Development and validation of a predictive model to forecast the cerebrovascular risk burden in older people using the NACC and ROSMAP dataset

Microbleeds, microinfarcts, and infarcts often precede clinical stroke and vascular dementia. We developed and validated the Cerebrovascular Disease Burden Risk Score (CDBRS), a new and interpretable model for stratifying the risk of microbleeds, microinfarcts, and infarcts in older adults. This tool developed using National Alzheimer's Coordinating Center (NACC) participants data achieved promising predictive performance in Religious Orders Study and Memory and Aging Project (ROSMAP) participants. The robust predictive performance warrants its clinical validation is prospective studies.