<i>Porphyromonas gingivalis</i> OMVs inhibit osteogenic differentiation of BMSCs via SAA3/TLR4/MyD88/NF-κB axis
Our results indicate that <i>P.g</i>-OMVs inhibit osteogenic differentiation of BMSCs via the SAA3-mediated TLR4/MyD88/NF-κB axis, providing novel targets for the treatment of periodontitis-induced alveolar bone loss.
Authors
- Qing Ge (ORCID: https://orcid.org/0000-0001-7377-9666)
- Hong‐Wen Deng (ORCID: https://orcid.org/0000-0002-0387-8818)
- Hong Shi He (ORCID: https://orcid.org/0000-0002-3983-2512)
- Janak Lal. Pathak (ORCID: https://orcid.org/0000-0003-2576-443X)
- Gang Wu (ORCID: https://orcid.org/0000-0001-8941-2500)
- Richard T. Jaspers (ORCID: https://orcid.org/0000-0002-6951-0952)
- Haiyan Wang (ORCID: https://orcid.org/0000-0003-2414-1919)
- Qing Zhang (ORCID: https://orcid.org/0000-0003-0404-5743)
- Jun Chen (ORCID: https://orcid.org/0000-0003-2447-0544)
- Jun Zha
- Yongyong Yan
- Haiyan Deng
Institutions
- Leiden University Medical Center (NL)
- First Affiliated Hospital of Guangdong Pharmaceutical University (CN)
- Stomatology Hospital (CN)
- Hangzhou Medical College (CN)
- Vrije Universiteit Amsterdam (NL)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Journal of Oral Microbiology
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1080/20002297.2025.2540823
- Citations
- 2
- Primary Topic
- Oral microbiology and periodontitis research
- Type
- article
- Field-Weighted Citation Impact
- 2.93
Funders
- National Natural Science Foundation of China