Association between the monocyte-to-high-density lipoprotein cholesterol ratio and abdominal aortic calcification in adults: Insights from the National Health and Nutrition Examination Survey (2013–2014)

BackgroundThis cross-sectional study aimed to investigate the association between the monocyte-to-high-density lipoprotein cholesterol ratio and abdominal aortic calcification in adults aged ≥40 years in the United States using data from the 2013-2014 National Health and Nutrition Examination Survey.MethodMultivariable logistic regression and restricted cubic splines models were used to assess the association between the monocyte-to-high-density lipoprotein cholesterol ratio and abdominal aortic calcification.ResultsAmong 2665 participants, 800 were diagnosed with abdominal aortic calcification. Multivariable logistic regression analysis revealed a positive association between the monocyte-to-high-density lipoprotein cholesterol ratio and abdominal aortic calcification (odds ratio: 1.33; 95% confidence interval: 1.13-1.57), and a nonlinear dose-response relationship was observed. Subgroup analysis suggested that the relationship between the monocyte-to-high-density lipoprotein cholesterol ratio and abdominal aortic calcification was more pronounced in females and nonsmokers.ConclusionsThe monocyte-to-high-density lipoprotein cholesterol ratio was positively associated with the prevalence of abdominal aortic calcification among individuals aged ≥40 years. A persistently elevated monocyte-to-high-density lipoprotein cholesterol ratio may contribute to an increased burden of abdominal aortic calcification.