Changes in bone marrow fat fraction and immune cell counts in women with cervical cancer treated with primary chemoradiotherapy
Vertebral fat fraction increased during treatment for dose > 1 Gy, without post-treatment recovery for dose > 5 Gy. Immunosuppression persisted up to 12 months post-treatment and was related to a higher mean vertebral PDFF. 5 Gy might be relevant for BM damage, but this threshold should be validated.
Authors
- Uulke A. van der Heide (ORCID: https://orcid.org/0000-0002-4146-6419)
- Jérémy Godart (ORCID: https://orcid.org/0000-0001-5070-8128)
- Anouk Corbeau (ORCID: https://orcid.org/0000-0003-3919-5135)
- Judith R. Kroep (ORCID: https://orcid.org/0000-0003-2671-1903)
- Remi A. Nout (ORCID: https://orcid.org/0000-0001-8011-2982)
- IA Boere (ORCID: https://orcid.org/0000-0002-4857-6346)
- M.S. Hoogeman
- Sjoerd H. van der Burg (ORCID: https://orcid.org/0000-0002-6556-0354)
- Eleftheria Astreinidou (ORCID: https://orcid.org/0000-0003-1691-8169)
- Willemien Visser
- Mila Donker
- Piotr A. Wielopolski (ORCID: https://orcid.org/0000-0002-8848-3451)
- Jan Willem Mens (ORCID: https://orcid.org/0000-0002-6363-8410)
- Marij J.P. Welters (ORCID: https://orcid.org/0000-0002-9809-8266)
- Sander Kuipers
- Hein Putter (ORCID: https://orcid.org/0000-0001-5395-1422)
- Carien L. Creutzberg (ORCID: https://orcid.org/0000-0002-7008-4321)
- Laura A. Velema (ORCID: https://orcid.org/0000-0003-3455-3407)
- Henrike Westerveld
- Suzanne Boer
Institutions
- Leiden University Medical Center (NL)
- Oncode Institute (NL)
- Erasmus MC Cancer Institute (NL)
- Rotterdam University of Applied Sciences (NL)
Publication Details
- Journal
- Radiotherapy and Oncology
- Published
- 2025-08-09
- DOI
- https://doi.org/10.1016/j.radonc.2025.111089
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Varian Medical Systems
- Siemens Healthineers