Gastrodin Attenuates Cerebral Ischemia–Reperfusion Injury by Enhancing Mitochondrial Fusion and Activating the <scp>AMPK</scp>‐<scp>OPA1</scp> Signaling Pathway
Gas alleviates cerebral I/R injury by regulating mitochondrial dynamics via the AMPK-OPA1 signaling pathway. These findings provide a theoretical basis for the therapeutic application of Gas in stroke and offer new insights into mitochondrial-targeted treatment strategies.
Authors
- Zeyu Han
- Jianming Cheng
- Yihan Guo (ORCID: https://orcid.org/0009-0006-6286-3807)
- Jie Zhang (ORCID: https://orcid.org/0000-0002-2497-725X)
- Zihan Liu (ORCID: https://orcid.org/0000-0002-3438-7130)
- Wei Bao (ORCID: https://orcid.org/0000-0002-3942-7218)
- Yuan Yuan (ORCID: https://orcid.org/0009-0002-9540-2100)
- Yang Hu (ORCID: https://orcid.org/0000-0002-1759-5085)
Institutions
- Nanjing University of Chinese Medicine (CN)
- China Pharmaceutical University (CN)
- Xi’an Jiaotong-Liverpool University (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1111/cns.70559
- Citations
- 3
- Primary Topic
- Neuroinflammation and Neurodegeneration Mechanisms
- Type
- article
- Field-Weighted Citation Impact
- 2.53
Funders
- National Key Research and Development Program of China