The role of formin-like protein 1 in pancreatic cancer and its specific effects on immunity

ObjectiveTo investigate the functions and immunological implication of formin-like protein 1 in pancreatic cancer.MethodsA multitude of public datasets and an in-house cohort were used to assess the clinical relevance and the immunological relevance of formin-like protein 1 in pancreatic cancer. Subsequently, in vitro assays were conducted to evaluate the biological roles of formin-like protein 1 in pancreatic cancer and its effects on immunity.ResultsThe expression of formin-like protein 1 was elevated in pancreatic cancer tissues and linked to a poor prognosis in pancreatic cancer. In vitro assays showed that elevated expression of formin-like protein 1 promoted pancreatic cancer progression. Moreover, formin-like protein 1 was linked to an inflamed tumor microenvironment and mediated epithelial-mesenchymal transition and programmed cell death 1 ligand 1 expression in pancreatic cancer.ConclusionsFormin-like protein 1 is a biomarker of an inflamed tumor microenvironment and positively modulates epithelial-mesenchymal transition and programmed cell death 1 ligand 1 expression in pancreatic cancer, which could be utilized as a novel target for antitumor immunity for more in-depth studies.