Stellarin I: A Bioactive Cyclic Nonapeptide with Potent Anti‐renal Fibrosis Activity from the Root of <i>Stellaria yunnanensis</i> Franch
An undescribed cyclic nonapeptide (1) was isolated from the crude root extract of the medicinal plant Stellaria yunnanensis Franch. Comprehensive spectral analysis was performed utilizing high-resolution mass spectrometry, one- and two-dimensional nuclear magnetic resonance spectroscopy, and experimental and calculated circular dichroism spectroscopy to elucidate the structure of the cyclic nonapeptide (1), which was identified as cyclo-(Tyr-Ala-Thr-Leu-Thr-Ala-Phe-Ala-Thr). Anti-renal fibrosis activity evaluation of compounds 1-3 showed that they have potential for anti-renal fibrosis by reducing the expression of fibrotic protein collagen I in NRK-49F cells induced by TGF-β1.
Authors
- Yong-Cheng Yang (ORCID: https://orcid.org/0000-0001-5499-5339)
- Chao Gu (ORCID: https://orcid.org/0000-0002-4358-4531)
- Conglong Xia (ORCID: https://orcid.org/0000-0002-8183-7595)
- Ruixue Deng (ORCID: https://orcid.org/0000-0002-0301-0429)
- Jiqun Wang (ORCID: https://orcid.org/0000-0003-2360-8329)
- Faliang An (ORCID: https://orcid.org/0000-0002-3011-4741)
- Xiujuan Xin
- Jian Li (ORCID: https://orcid.org/0000-0002-0864-5108)
- Xiaokang Li (ORCID: https://orcid.org/0000-0001-8392-3211)
Institutions
- Shihezi University (CN)
- East China University of Science and Technology (CN)
- Dali University (CN)
Publication Details
- Journal
- Chemistry & Biodiversity
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1002/cbdv.202502177
- Citations
- 1
- Primary Topic
- Phytochemistry and Bioactivity Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.56
Funders
- Innovative Research Group Project of the National Natural Science Foundation of China
- National Natural Science Foundation of China