Synergistic epigenetic modulation by 5-aza-2’-deoxycytidine and Wnt3a drives osteogenic trans-differentiation of 3T3-L1 pre-adipocytes through <i>Ywhah</i> and <i>Ywhae</i>
Combining 5azaC-induced demethylation with Wnt3a is a potent strategy to redirect pre-adipocytes toward osteogenesis. Identification of key targets like Ywhah and Ywhae provides mechanistic insight into trans-differentiation and suggests therapeutic potential for bone regeneration, particularly in elderly periodontal patients.
Authors
- Young‐Dan Cho (ORCID: https://orcid.org/0000-0002-4694-5988)
- Seung Gwa Park
- Woo Jin Kim (ORCID: https://orcid.org/0000-0003-2927-370X)
- Ki Tae Kim (ORCID: https://orcid.org/0000-0002-5692-1189)
- Sungtae Kim (ORCID: https://orcid.org/0000-0001-6361-4104)
Institutions
- Seoul National University (KR)
- Seoul National University Dental Hospital (KR)
Publication Details
- Journal
- Epigenomics
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1080/17501911.2025.2544513
- Primary Topic
- Epigenetics and DNA Methylation
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Seoul National University