Exploratory investigation of urinary alkanes and other volatile organic compounds in paediatric patients with tuberculous meningitis
This study discovered new systemic metabolic information about M. tb in the host and the role of alkanes and VOCs in the potential persistence of M. tb. We demonstrate the value of targeting alkanes and other VOCs for future metabolomics studies of M. tb.
Authors
- Simon Isaiah (ORCID: https://orcid.org/0000-0002-7471-3877)
- Shayne Mason (ORCID: https://orcid.org/0000-0002-2945-5768)
- Du Toit Loots (ORCID: https://orcid.org/0000-0002-0339-6237)
- Sabine van Elsland (ORCID: https://orcid.org/0000-0003-0775-7463)
- A. Marceline van Furth (ORCID: https://orcid.org/0000-0003-1666-8956)
- Regan Solomons (ORCID: https://orcid.org/0000-0002-5607-8443)
- Martijn van der Kuip (ORCID: https://orcid.org/0000-0003-1484-360X)
Institutions
- Western Cape Department of Health (ZA)
- Stellenbosch University (ZA)
- North-West University (ZA)
- Amsterdam University Medical Centers (NL)
- Imperial College London (GB)
Publication Details
- Journal
- Metabolomics
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1007/s11306-025-02304-5
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- North-West University