Methotrexate-induced epidermal necrosis

Methotrexate-induced epidermal necrosis is an uncommon, potentially fatal, adverse reaction to methotrexate. Early diagnosis of methotrexate-induced epidermal necrosis can prompt early intervention with calcium folinate and hopefully mitigate potentially fatal outcomes associated with methotrexate toxicity.

Authors

John A. Thompson (ORCID: https://orcid.org/0000-0001-8739-5380)
Christopher J. Kennedy

Institutions

Oregon Health & Science University (US)
Washington Poison Center (US)

Publication Details

Journal: Clinical Toxicology
Published: 2025-08-12
DOI: https://doi.org/10.1080/15563650.2025.2532616
Citations: 2
Primary Topic: Drug-Induced Adverse Reactions
Type: article
Field-Weighted Citation Impact: 2.79

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article

Methotrexate-induced epidermal necrosis

John A. Thompson, Christopher J. Kennedy

Aug 12, 2025

2 citations

Clinical Toxicology

Drug-Induced Adverse Reactions

2.79

article

Methotrexate-induced epidermal necrosis

John A. Thompson, Christopher J. Kennedy

August 12, 2025article en

2 citations

Abstract

Clinical ToxicologyVol. 63(10)

Oregon Health & Science University (US), Washington Poison Center (US)

Openalex Percentile: Top 9%

Drug-Induced Adverse Reactions

2.79

DOI Source OpenAlex

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Methotrexate-induced epidermal necrosis — John A. Thompson, Christopher J. Kennedy · Clinical Toxicology (2025) | TGRS Research Map | TGRS