Activation of integrin signaling up-regulates pro-inflammatory cytokines in JAK2-V617F positive hematopoietic cells
We conclude that integrin stimulation via the adhesion molecules VCAM-1/ICAM-1 activates integrin outside-in signaling, leading to the up-regulation of pro-inflammatory cytokines in both JAK2-mutated and non-mutated mouse hematopoietic cells.
Authors
- Martin Böttcher (ORCID: https://orcid.org/0000-0003-2911-8830)
- Vikas Bhuria (ORCID: https://orcid.org/0000-0003-0891-5689)
- Corinna Fahldieck
- Daniel B. Lipka (ORCID: https://orcid.org/0000-0001-5081-7869)
- T Fischer (ORCID: https://orcid.org/0000-0002-9542-322X)
- Conny K. Baldauf (ORCID: https://orcid.org/0000-0002-9653-8715)
- Tobias Ronny Haage (ORCID: https://orcid.org/0009-0003-4303-1683)
- Dimitrios Mougiakakos (ORCID: https://orcid.org/0000-0002-2817-6660)
- M. R. Hakobyan (ORCID: https://orcid.org/0009-0001-4527-3913)
- Sönke Weinert (ORCID: https://orcid.org/0000-0002-7201-0836)
- Burkhart Schraven (ORCID: https://orcid.org/0000-0003-4321-7405)
- Alexa Angenstein
Institutions
- German Cancer Research Center (DE)
- Heidelberg University (DE)
- University Hospital Heidelberg (DE)
- National Center for Tumor Diseases (DE)
- Deutsches Konsortium für Translationale Krebsforschung (DE)
- Epigenomics (Germany) (DE)
- Otto-von-Guericke-Universität Magdeburg (DE)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s12964-025-02358-x
- Primary Topic
- Myeloproliferative Neoplasms: Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Otto von Guericke University Magdeburg