Age: A Moderating Effect on Cerebrospinal Fluid Fibroblast Growth Factor 21 and Cognitive Function
This is the first study to report that age plays a moderating effect in the relationship between CSF FGF21 and cognition. Moreover, higher CSF FGF21 levels have a protective effect on cognition in individuals aged ≤34 years old. However, individuals aged>34 years old can improve cognition via alternative strategies.
Authors
- Ying Tao (ORCID: https://orcid.org/0000-0003-4810-5998)
- Suriyakala Perumal Chandran (ORCID: https://orcid.org/0000-0001-6904-7980)
- Yanlong Liu (ORCID: https://orcid.org/0000-0001-8733-8028)
- Danyang Zhao (ORCID: https://orcid.org/0000-0002-1332-6101)
- Jiubo Fan (ORCID: https://orcid.org/0000-0003-4663-3201)
- Ligang Shan (ORCID: https://orcid.org/0000-0002-7886-4322)
- Fan Wang (ORCID: https://orcid.org/0000-0002-7048-8166)
- Xiaoli Han (ORCID: https://orcid.org/0000-0002-4297-8934)
- Yuyu Zhou
Institutions
- Peking University (CN)
- Wenzhou Medical University (CN)
- First Affiliated Hospital of Xiamen University (CN)
- Yili Friendship Hospital (CN)
- Hubei University of Arts and Science (CN)
- Xiangyang Central Hospital (CN)
- Lincoln University College (MY)
- Beijing HuiLongGuan Hospital (CN)
- Urumqi General Hospital of PLA (CN)
- Xiamen Chang Gung Hospital (CN)
- The Second Affiliated Hospital of Xiamen Medical College
- Inner Mongolia Medical University (CN)
Publication Details
- Journal
- Brain and Behavior
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1002/brb3.70784
- Primary Topic
- Fibroblast Growth Factor Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Xinjiang Province
- Inner Mongolia Medical University
- National Natural Science Foundation of China
- Natural Science Foundation of Fujian Province
- Natural Science Foundation of Inner Mongolia
- Natural Science Foundation of Beijing Municipality
- Natural Science Foundation of Xinjiang