Endometrial carcinoma and immune escape: prognostic relevance of <scp>HLA</scp> class I loss in <scp>NSMP</scp> subtype
HLA-I loss defines a biologically aggressive subgroup within NSMP ECs and is associated with adverse clinicopathologic and immune features. Assessment of HLA-I expression could refine risk stratification in NSMP ECs, a group traditionally lacking robust prognostic markers and may help identify patients who could benefit from intensified clinical surveillance and future immunomodulatory treatment strategies.
Authors
- Jacopo Lenzi (ORCID: https://orcid.org/0000-0003-2882-4223)
- Antonio De Leo (ORCID: https://orcid.org/0000-0002-3761-5135)
- Alessia Ciarrocchi (ORCID: https://orcid.org/0000-0002-5541-2075)
- Anna Myriam Perrone (ORCID: https://orcid.org/0000-0003-3140-4772)
- Benedetta Donati (ORCID: https://orcid.org/0000-0002-9163-8194)
- C. Zamagni (ORCID: https://orcid.org/0000-0002-7143-9091)
- Sabrina Croce (ORCID: https://orcid.org/0000-0002-6487-5418)
- Caterina Ravaioli
- Laura Poppi (ORCID: https://orcid.org/0000-0002-7353-8237)
- Sara Coluccelli (ORCID: https://orcid.org/0000-0002-1475-4044)
- Dario de Biase (ORCID: https://orcid.org/0000-0002-0609-8817)
- Riccardo Ciudino (ORCID: https://orcid.org/0009-0006-7245-584X)
- Thais Maloberti (ORCID: https://orcid.org/0000-0002-8306-4653)
- Marco Grillini (ORCID: https://orcid.org/0000-0003-2506-7239)
- Camelia Alexandra Coadǎ (ORCID: https://orcid.org/0000-0001-8362-6639)
- Giovanni Tallini (ORCID: https://orcid.org/0000-0003-0113-6682)
- Pierandrea De Iaco (ORCID: https://orcid.org/0000-0002-8841-6531)
- Martin Köbel (ORCID: https://orcid.org/0000-0002-6615-2037)
- Claudio Ceccarelli (ORCID: https://orcid.org/0000-0003-0743-2087)
- Gloria Ravegnini (ORCID: https://orcid.org/0000-0002-7774-402X)
- Cheng‐Han Lee (ORCID: https://orcid.org/0000-0003-2094-1222)
- Daniela Rubino
Institutions
- University of Alberta (CA)
- University of Calgary (CA)
- Iuliu Hațieganu University of Medicine and Pharmacy (RO)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Ospedale Santa Maria (IT)
- Azienda USL di Bologna (IT)
- Institut Bergonié (FR)
- University of Bologna (IT)
Publication Details
- Journal
- Histopathology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1111/his.15531
- Citations
- 1
- Primary Topic
- Endometrial and Cervical Cancer Treatments
- Type
- article
- Field-Weighted Citation Impact
- 2.06
Funders
- Associazione Italiana per la Ricerca sul Cancro