Definition of lines of treatment in metastatic colorectal cancer: a Delphi consensus

This study highlights significant variability in the definition of LoTs for mCRC, which reflects the evolution of therapeutic landscape. The divergence between clinical trial criteria and real-world practices underscores the need for standardized definitions to enhance consistency in clinical decision-making. Refinement of guidelines on biologic agents, rechallenge strategies, and therapy classification is critical to advance mCRC management and improve patient outcomes. This consensus serves as a foundation for future research and guideline development.

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Publication Details

Journal
Clinical & Translational Oncology
Published
2025-08-11
DOI
https://doi.org/10.1007/s12094-025-03986-y
Primary Topic
Colorectal Cancer Treatments and Studies
Type
article
Field-Weighted Citation Impact
0.00
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article

Definition of lines of treatment in metastatic colorectal cancer: a Delphi consensus

Ana Fernández Montés, Julia Alcaide, C. Santos Vivas, Élena Elez et al.
Clinical & Translational Oncology
Colorectal Cancer Treatments and Studies
article

Definition of lines of treatment in metastatic colorectal cancer: a Delphi consensus

Ana Fernández Montés, Julia Alcaide, C. Santos Vivas, Élena Elez, Paula Jiménez‐Fonseca, Cristina Grávalos, Ignacio García Escobar, Enrique Aranda, Javier Sastre, C. Montagut Viladot, Pilar García‐Alfonso, I. Matos Garcia, Noelia Tarazona
article en

Abstract

This study highlights significant variability in the definition of LoTs for mCRC, which reflects the evolution of therapeutic landscape. The divergence between clinical trial criteria and real-world practices underscores the need for standardized definitions to enhance consistency in clinical decision-making. Refinement of guidelines on biologic agents, rechallenge strategies, and therapy classification is critical to advance mCRC management and improve patient outcomes. This consensus serves as a foundation for future research and guideline development.

Clinical & Translational OncologyVol. 28(2)
Hebron University (PS), Universitat Pompeu Fabra (ES), Hospital General Universitario Gregorio Marañón (ES), Hospital Clínico San Carlos (ES), Institut d'Investigació Biomédica de Bellvitge (ES), Hospital Clínico Universitario de Valencia (ES), Hospital Universitario 12 De Octubre (ES), Vall d'Hebron Institut de Recerca (ES), Institut Català d'Oncologia (ES), Hospital Regional Universitario de Málaga (ES), Hospital Universitario Reina Sofía (ES), Vall d'Hebron Hospital Universitari (ES), Hospital Del Mar (ES), Hospital Universitario Central de Asturias (ES), Clinica Universidad de Navarra (ES), Complejo Hospitalario Universitario de Toledo (ES), Instituto de Investigación Biomédica de Málaga (ES), Complejo Hospitalario de Ourense (ES), Hospital Universitario de Toledo (ES)
Peace, Justice and strong institutions
Openalex Percentile: Top 71%
Colorectal Cancer Treatments and Studies
DOIOpen Access PDFOpenAlex
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