Biomarker identification through spatial proteomics for the characterization of indeterminate thyroid nodules
The LDA-selected features enable to distinguish NIFTPs from morphologically similar lesions and to discriminate between mNRAS and wtNRAS cases. The identified markers might complement genetic analyses and provide insights into the distinct pathogenic drivers behind the development of mNRAS compared to wtNRAS lesions.
Authors
- Isabella Piga (ORCID: https://orcid.org/0000-0001-8221-2493)
- Angela Greco (ORCID: https://orcid.org/0000-0003-2994-0349)
- Davide Leni
- Vincenzo L’Imperio (ORCID: https://orcid.org/0000-0002-9284-2998)
- Nicola Fusco (ORCID: https://orcid.org/0000-0002-9101-9131)
- Mattia Garancini (ORCID: https://orcid.org/0000-0001-6091-4574)
- Stefania Galimberti (ORCID: https://orcid.org/0000-0003-1504-7242)
- Giulia Capitoli (ORCID: https://orcid.org/0000-0002-8178-2440)
- Fausto Maffini (ORCID: https://orcid.org/0000-0002-4554-8956)
- Fulvio Magni (ORCID: https://orcid.org/0000-0002-8663-0374)
- Fabio Pagni (ORCID: https://orcid.org/0000-0001-9625-1637)
- Davide Paolo Bernasconi (ORCID: https://orcid.org/0000-0001-8771-5428)
- Lisa Pagani (ORCID: https://orcid.org/0000-0002-9870-932X)
- Andrea-Valer Gatti
- Angelo Maggioni
- Vanna Denti (ORCID: https://orcid.org/0000-0001-6373-689X)
- Nicole Monza (ORCID: https://orcid.org/0009-0003-9392-8069)
- Antonio Maria Alviano
Institutions
- University of Cagliari (IT)
- University of Milan (IT)
- Azienda Ospedaliera San Gerardo (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- European Institute of Oncology (IT)
- University of Milano-Bicocca (IT)
Publication Details
- Journal
- Endocrine
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1007/s12020-025-04383-9
- Citations
- 2
- Primary Topic
- Thyroid Cancer Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 2.59
Funders
- Università degli Studi di Milano
- Dipartimenti di Eccellenza
- European Commission
- Ministero della Salute