Cerebrospinal fluid quantitative proteomic reveals potential mechanisms and biomarker candidates of children with bacterial meningitis complicated by neurological complications
This study identified distinct CSF protein expression profiles in children with BMN, BM, and Ctrl, potentially enhancing our understanding of the molecular mechanisms underlying bacterial meningitis. These protein signatures help us distinguish bacterial meningitis from the Ctrl group. Furthermore, selected biomarkers could support the differentiation between BMN and BM.
Authors
- Liang Zhu (ORCID: https://orcid.org/0000-0002-6529-5706)
- Wanrong Li (ORCID: https://orcid.org/0000-0003-4645-2726)
- Xixi Zhang (ORCID: https://orcid.org/0000-0002-0944-2214)
- Kaihu Yao
- Bing Hu (ORCID: https://orcid.org/0000-0001-5085-3114)
- Binglin Jian
- Lingyun Guo (ORCID: https://orcid.org/0000-0001-9021-4341)
- Lulu Jia (ORCID: https://orcid.org/0000-0002-3453-353X)
- Zhengguang Guo (ORCID: https://orcid.org/0000-0002-5983-7759)
- Bing Liu (ORCID: https://orcid.org/0000-0002-7313-6924)
- Linlin Liu (ORCID: https://orcid.org/0000-0001-5093-7940)
- Gang Liu (ORCID: https://orcid.org/0000-0003-2492-4833)
- Juan Du (ORCID: https://orcid.org/0000-0001-6199-0157)
- YangQuan Chen (ORCID: https://orcid.org/0000-0002-7422-5988)
- Wei Sun (ORCID: https://orcid.org/0000-0002-1493-8249)
- Jing Wei (ORCID: https://orcid.org/0000-0001-7457-0688)
- Yue Xie (ORCID: https://orcid.org/0000-0003-0557-7418)
Institutions
- Capital Medical University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Beijing Children’s Hospital (CN)
Publication Details
- Journal
- Clinical Proteomics
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s12014-025-09548-2
- Primary Topic
- Bacterial Infections and Vaccines
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Beijing Municipal Administration of Hospitals
- Peking Union Medical College
- Wu Jieping Medical Foundation
- Beijing Children's Hospital, Capital Medical University