Analysis of the clinical value and influencing factors of combined detection of tuberculosis-specific cytokines IFN-γ and IL-2 in the diagnosis of active tuberculosis in children and adolescents
In pediatric and adolescent patients, the combined detection of IFN-γ and IL-2 exhibits high sensitivity and specificity in diagnosing ATB. The test is convenient, stable, and highly accurate, making it of great significance for the early diagnosis of TB and the evaluation of treatment effects. Age, a positive TST result, retreatment TB, and the presence of pleural effusion may all influence the results of IFN-γ and/or IL-2.
Authors
- Li Gao (ORCID: https://orcid.org/0000-0001-6470-5905)
- Jing Han (ORCID: https://orcid.org/0000-0001-8705-5095)
- Shenjie Tang (ORCID: https://orcid.org/0000-0002-9131-4165)
- Lei Chen (ORCID: https://orcid.org/0009-0003-4906-5163)
- Jinyu Chen (ORCID: https://orcid.org/0000-0003-1625-5879)
- Bin Deng (ORCID: https://orcid.org/0000-0001-8347-1104)
- Yuhong Huang (ORCID: https://orcid.org/0000-0001-5466-8581)
- Qiong Li (ORCID: https://orcid.org/0009-0001-2116-4683)
- Maoying Li (ORCID: https://orcid.org/0009-0003-2951-7134)
Institutions
- Beijing Chest Hospital (CN)
- Public Health Clinical Center of Chengdu (CN)
Publication Details
- Journal
- European journal of medical research
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1186/s40001-025-02895-8
- Citations
- 1
- Primary Topic
- Tuberculosis Research and Epidemiology
- Type
- article
- Field-Weighted Citation Impact
- 1.40