Monitoring the Evolution of Dry Eye Disease in Rabbits with Advanced Ocular Keratography: Implications for Translational Studies
AKU technology can effectively detect changes in multiple parameters during the evolution and resolution of DED in rabbits. DED parameters showed similar patterns for most variables in both humans and rabbits demonstrating great potential of this device in translational research. The AKU can also follow additional parameters evaluating the responses of the lacrimal functional unit. Our findings document the applicability of this technology for translational studies of DED and underscores its potential to further refine understanding of the disease pathophysiology.
Authors
- Michael Wolek (ORCID: https://orcid.org/0000-0002-4040-4507)
- Ishan Amin Khwaja
- Kevin Kaplowitz
- Barbara Nemesure (ORCID: https://orcid.org/0000-0003-4278-9540)
- Konstantinos Tourmouzis (ORCID: https://orcid.org/0000-0001-7095-6006)
- Basil Rigas (ORCID: https://orcid.org/0000-0002-1758-6939)
- Robert Honkanen
- Timothy Chou (ORCID: https://orcid.org/0000-0003-4351-5533)
- Brian M. Wollocko (ORCID: https://orcid.org/0000-0002-1422-9987)
- Nicholas Fazio (ORCID: https://orcid.org/0000-0002-8325-6778)
- Liqun Huang (ORCID: https://orcid.org/0009-0004-3133-3657)
- Emily K. White (ORCID: https://orcid.org/0009-0005-3295-9712)
Institutions
- State University of New York (US)
- Queen Mary University of London (GB)
- Stony Brook University Hospital (US)
- Renaissance University (NG)
- Stony Brook School (US)
- VA Loma Linda Healthcare System (US)
- Stony Brook University (US)
Publication Details
- Journal
- Current Eye Research
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1080/02713683.2025.2527726
- Primary Topic
- Ocular Surface and Contact Lens
- Type
- article
- Field-Weighted Citation Impact
- 0.00