Electrochemical Deoxygenative Silylation of Alcohols
Alcohols are highly common organic compounds but remain scarce as alkyl donors in synthetic procedures. Here, we describe an electrochemical procedure for their deoxygenative cross-electrophile coupling with hydrosilanes, furnishing organosilane products in good to excellent yields. Mechanistic studies provide insights into the operating pathways of this semi-paired electrolytic transformation, suggesting that silyl ethers are likely reaction intermediates. Furthermore, a unified mechanistic proposal is presented that accounts for observed reactivity differences with analogous deoxygenative electrocarboxylation.
Authors
- Helena Lundberg (ORCID: https://orcid.org/0000-0002-4704-1892)
- Kevin Breitwieser (ORCID: https://orcid.org/0000-0002-7012-8750)
- Malin Lill (ORCID: https://orcid.org/0009-0003-1445-0184)
- Mårten S. G. Ahlquist (ORCID: https://orcid.org/0000-0002-1553-4027)
- J.M. White (ORCID: https://orcid.org/0000-0002-9181-9825)
- Piret Villo (ORCID: https://orcid.org/0000-0002-1021-5094)
- Ziwei Fan (ORCID: https://orcid.org/0009-0000-5769-2587)
- Sergio Pérez Morente
Institutions
- KTH Royal Institute of Technology (SE)
Publication Details
- Journal
- Angewandte Chemie International Edition
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1002/anie.202508697
- Citations
- 5
- Primary Topic
- Radical Photochemical Reactions
- Type
- article
- Field-Weighted Citation Impact
- 4.68
Funders
- National Science Foundation
- Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
- Stiftelsen för Strategisk Forskning
- National Science Council
- Stiftelsen Olle Engkvist Byggmästare
- Vetenskapsrådet
- China Scholarship Council
- European Research Council
- National Supercomputing Center, Korea Institute of Science and Technology Information