Independent effects of mental health disorders on breast cancer and their mediating factors: evidence from NHANES and two-step Mendelian randomization
Our findings suggests that anxiety susceptibility at the genetic level is a distinct risk factor for BC, with no mediators identified in this process.
Authors
- Kang Ma (ORCID: https://orcid.org/0000-0002-2600-7150)
- Xueyan Mao (ORCID: https://orcid.org/0000-0002-5306-5970)
- Hongkai Zhuang (ORCID: https://orcid.org/0009-0009-0293-4724)
- Long Cheng (ORCID: https://orcid.org/0000-0002-4752-1298)
- Bo Chen (ORCID: https://orcid.org/0000-0002-9099-6248)
Institutions
- Sun Yat-sen University (CN)
- Sun Yat-sen Memorial Hospital (CN)
- Shanghai University of Traditional Chinese Medicine (CN)
- Yueyang Hospital (CN)
- Guangdong Academy of Medical Sciences (CN)
- South China University of Technology (CN)
- University of South China (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1007/s12672-025-03261-0
- Primary Topic
- BRCA gene mutations in cancer
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China
- Guangdong Provincial People's Hospital
- Basic and Applied Basic Research Foundation of Guangdong Province