Optimizing T cell transduction: a novel transduction device for efficient and scalable gene delivery

These findings suggest that TransB could significantly shorten the transduction time, reduce the transduction cost and improve the transduction efficiency for manufacturing genetically modified T cell therapies. It shows strong potential as a robust, efficient, and scalable platform to enhance T cell therapy manufacturing and help overcome current manufacturing challenges in the field.

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Publication Details

Journal
Journal of Translational Medicine
Published
2025-08-12
DOI
https://doi.org/10.1186/s12967-025-06836-1
Primary Topic
CAR-T cell therapy research
Type
article
Field-Weighted Citation Impact
0.00

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article

Optimizing T cell transduction: a novel transduction device for efficient and scalable gene delivery

Tan Dai Nguyen, Kang-Zheng Lee, Liu Dan
4 links
Journal of Translational Medicine
CAR-T cell therapy research
article

Optimizing T cell transduction: a novel transduction device for efficient and scalable gene delivery

Tan Dai Nguyen, Kang-Zheng Lee, Liu Dan
article en

Abstract

These findings suggest that TransB could significantly shorten the transduction time, reduce the transduction cost and improve the transduction efficiency for manufacturing genetically modified T cell therapies. It shows strong potential as a robust, efficient, and scalable platform to enhance T cell therapy manufacturing and help overcome current manufacturing challenges in the field.

Journal of Translational MedicineVol. 23(1)
Bioprocessing Technology Institute (SG)
Agency for Science, Technology and Research
Openalex Percentile: Top 71%
CAR-T cell therapy research
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