Allelic Cataloging of <i>RHD–RHCE</i> Reference Sequences Using Targeted Long-Read Sequencing
Our findings revealed that the current Eurasian allelic pool originated from 2 distinct primordial lineages, with occasional interallelic recombination events shaping the present-day RHD-RHCE haplotype diversity. While most previous classification approaches have treated RHD and RHCE independently, our results support the notion that analyzing them as a single evolutionary unit may offer practical advantages for molecular typing approaches.
Authors
- Dae‐Hyun Ko (ORCID: https://orcid.org/0000-0002-9781-0928)
- Soon Sung Kwon (ORCID: https://orcid.org/0000-0002-7000-9284)
- Jong Rak Choi (ORCID: https://orcid.org/0000-0002-0608-2989)
- Eun Jung Suh (ORCID: https://orcid.org/0009-0004-4737-8657)
- Junhyup Song
- Hyun-Kyung Kim (ORCID: https://orcid.org/0000-0002-2528-6231)
- Sinyoung Kim
Institutions
- Ulsan College (KR)
- Severance Hospital (KR)
- Asan Medical Center (KR)
- University of Ulsan (KR)
- Gangnam Severance Hospital (KR)
Publication Details
- Journal
- Clinical Chemistry
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1093/clinchem/hvaf090
- Primary Topic
- Blood groups and transfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Research Foundation of Korea