NCOA4 inhibits glioma progression by suppressing the Sonic Hedgehog pathway and its overexpression indicates a better glioma prognosis
These results suggest that NCOA4 is downregulated in gliomas and that its overexpression predicts better overall survival in glioma patients. Mechanistically, NCOA4 overexpression inhibits the progression of glioma by suppressing the SHH pathway.
Authors
- Zhifan Jia
- Anling Zhang
- Guangxiu Wang
- Kaining Liu
- Hu Wang (ORCID: https://orcid.org/0009-0009-9026-9751)
- Tian Qiu (ORCID: https://orcid.org/0000-0002-8608-5863)
- Xiaoguang Tong (ORCID: https://orcid.org/0000-0003-4774-8625)
Institutions
- Tianjin Medical University General Hospital (CN)
- Tianjin Huanhu Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Genes & Genomics
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1007/s13258-025-01666-3
- Primary Topic
- Glioma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- National Natural Science Foundation of China