Personalized pulmonary vein isolation guided by left atrial wall thickness for persistent atrial fibrillation ablation: the PeAF-by-LAWT randomized trial
The PeAF-by-LAWT trial is the first prospective randomized study to demonstrate that a personalized LAWT-guided PVI for PeAF ablation is non-inferior to the standard CLOSE protocol in terms of arrhythmia-free survival while significantly improving procedural efficiency. The study was not powered to detect differences in safety outcomes.
Authors
- A Bellido
- Fátima Záraket (ORCID: https://orcid.org/0000-0002-0706-1987)
- Stefano Valcher (ORCID: https://orcid.org/0000-0001-8355-9894)
- Pietro Francia (ORCID: https://orcid.org/0000-0003-0306-7764)
- Andrea Saglietto (ORCID: https://orcid.org/0000-0001-9475-1507)
- Roberta Mea
- Alessia Chiara Latini (ORCID: https://orcid.org/0000-0002-6024-6278)
- Emanuele Curti
- Jose T. Ortiz‐Pérez (ORCID: https://orcid.org/0000-0001-8043-6055)
- Darío Turturiello (ORCID: https://orcid.org/0000-0001-9579-5413)
- Giulio Falasconi (ORCID: https://orcid.org/0000-0001-7128-9911)
- Lucio Teresi (ORCID: https://orcid.org/0000-0001-5626-0336)
- Marina Huguet (ORCID: https://orcid.org/0000-0002-3524-6612)
- David Soto‐Iglesias (ORCID: https://orcid.org/0000-0003-1394-6260)
- Diego Penela (ORCID: https://orcid.org/0009-0009-7221-4829)
- Julio Martí‐Almor (ORCID: https://orcid.org/0000-0001-9927-1190)
- Carlo Gigante (ORCID: https://orcid.org/0000-0003-2266-0344)
- Carmine De Lucia
- Chiara Valeriano (ORCID: https://orcid.org/0000-0002-0130-6218)
- Francesco Amata (ORCID: https://orcid.org/0000-0003-3651-6765)
- José Alderete (ORCID: https://orcid.org/0000-0003-0318-5349)
- Paula Franco-Ocaña (ORCID: https://orcid.org/0000-0002-6157-058X)
- Óscar Cámara (ORCID: https://orcid.org/0000-0002-5125-6132)
- Daniel Viveros (ORCID: https://orcid.org/0000-0002-8317-561X)
- Federico Landra (ORCID: https://orcid.org/0000-0002-2106-0884)
- Antonio Berruezo (ORCID: https://orcid.org/0000-0002-5418-383X)
- Bruno Tonello
- Lautaro Sánchez-Mollá
Institutions
- University of Siena (IT)
- University of Messina (IT)
- Humanitas University (IT)
- Universitat Pompeu Fabra (ES)
- University of Milan (IT)
- Centro Cardiologico Monzino (IT)
- Hospital Quirón Teknon (ES)
- Departament de Salut (ES)
- Open Evidence (ES)
- The Arrhythmia Institute (US)
- Azienda Ospedaliera Sant'Andrea (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Turin (IT)
- University of Milano-Bicocca (IT)
- Sapienza University of Rome (IT)
Publication Details
- Journal
- EP Europace
- Published
- 2025-08-04
- DOI
- https://doi.org/10.1093/europace/euaf163
- Citations
- 2
- Primary Topic
- Atrial Fibrillation Management and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 2.78