Soluble Fms-Like Tyrosine Kinase-1 Associates With Risk of Acute Respiratory Distress Syndrome and Mortality in Sepsis
Higher plasma levels of sFlt-1 were associated with an increased risk of ARDS and ARDS mediated a significant proportion of the sFlt-1-associated mortality observed during sepsis. Our findings further implicate dysregulated VEGF signaling in ARDS and suggest that plasma sFlt-1 merits further investigation as an early endothelial therapeutic target for sepsis-associated ARDS and mortality.
Authors
- M.G.S. Shashaty (ORCID: https://orcid.org/0000-0002-8766-3418)
- C.A.G. Ittner
- Balasubramanyam Karanam (ORCID: https://orcid.org/0000-0002-0782-2539)
- Todd A. Miano (ORCID: https://orcid.org/0000-0002-3832-6212)
- Nuala J. Meyer (ORCID: https://orcid.org/0000-0003-4597-5584)
- Brian J. Anderson (ORCID: https://orcid.org/0000-0002-2426-9683)
- Tiffanie K. Jones (ORCID: https://orcid.org/0000-0003-0058-8847)
- Rui Feng (ORCID: https://orcid.org/0000-0003-4151-7228)
- John P. Reilly (ORCID: https://orcid.org/0000-0003-3937-5320)
Institutions
- University of Pennsylvania (US)
Publication Details
- Journal
- Critical Care Explorations
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1097/cce.0000000000001294
- Primary Topic
- Phagocytosis and Immune Regulation
- Type
- article
- Field-Weighted Citation Impact
- 0.00