Schisandra chinensis mixture attenuates diabetic kidney disease via VDAC1/Grp75/IP3R-mediated MAMs stabilization and apoptosis-autophagy regulation
SM treats DKD by MAMs integrity through the VDAC1-Grp75-IP<sub>3</sub>R axis, regulating HG-stimulated apoptosis and autophagy in renal tubular cells, improving mitochondrial function, and suppressing fibrotic progression.
Authors
- Ao Dong
- Pengfei He (ORCID: https://orcid.org/0000-0002-5727-7188)
- Yu Ma (ORCID: https://orcid.org/0000-0002-6300-7280)
- Mianzhi Zhang (ORCID: https://orcid.org/0000-0002-2446-9829)
- Minying Zhang (ORCID: https://orcid.org/0000-0001-7461-7060)
- Hongdian Li (ORCID: https://orcid.org/0000-0002-4888-3469)
- Sai Zhang (ORCID: https://orcid.org/0009-0005-2457-5364)
- Shu Chen (ORCID: https://orcid.org/0009-0003-7567-2434)
- Shaoning Dong
- Cong Liu
Institutions
- Tianjin University of Traditional Chinese Medicine (CN)
- Beijing University of Chinese Medicine (CN)
- Nankai University (CN)
- Tianjin Nankai Hospital (CN)
- Beijing Fengtai Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1016/j.phymed.2025.157164
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- Natural Science Foundation of Beijing Municipality
- Tianjin Medical University
- Tianjin Municipal Science and Technology Bureau
- Tianjin Science and Technology Program