Clinical and survival differences between second primary and first primary nasopharyngeal carcinoma in a retrospective study
Second NPC is not rare. Significant differences in clinical profiles and prognosis between 2nd NPC and 1st NPC, particularly the paradox of earlier-stage diagnosis yet poorer survival and higher risk of disease progression in 2nd NPC, highlight the need for tailored screening, risk-stratified follow-up, and comorbidity-adapted therapies for cancer survivors.
Authors
- Min Kyu Kang (ORCID: https://orcid.org/0000-0002-1435-3312)
- Xin Huang (ORCID: https://orcid.org/0000-0002-0359-7290)
- Ying Kong (ORCID: https://orcid.org/0000-0001-5153-3235)
- Zhen Meng (ORCID: https://orcid.org/0000-0003-0131-4135)
- Tianyu Wu (ORCID: https://orcid.org/0000-0002-3528-7270)
Institutions
- Guangxi Medical University (CN)
- First Affiliated Hospital of GuangXi Medical University (CN)
Publication Details
- Journal
- Discover Oncology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1007/s12672-025-03250-3
- Citations
- 1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.85
Funders
- National Natural Science Foundation of China
- Natural Science Foundation of Guangxi Province
- Science and Technology Department of Guangxi Zhuang Autonomous
- Guangxi Medical University
- Guangxi Key Research and Development Program