From Mediterranean Fever to Autoimmune Hepatitis

Autoimmune hepatitis (AIH) is a chronic inflammatory liver disease of unknown etiology. It is a rare immune-mediated pathology without a typical clinical presentation and with a challenging diagnosis. The AIH has two types (types 1 and 2) that differ by the pattern of autoantibodies presented. Treatment is based on corticosteroid therapy with prednisolone, with or without azathioprine. The treatment aims to induce and maintain histological remission, improving symptoms and survival. Here, we present the case of a 72-year-old female patient admitted to the Internal Medicine Department with suspected toxic hepatitis associated with the use of cefuroxime. During hospitalization, due to lack of improvement after antibiotic discontinuation, an extensive etiological study was performed, with a diagnosis of type 1 AIH. After the histological diagnosis, she started the treatment with corticosteroids with a good therapeutic response.