The role of hyperthermia on abdominal tissue concentrations of cisplatin during and after intraperitoneal chemotherapy – insights from a porcine model
Hyperthermia did not enhance cisplatin's tissue penetration, suggesting that NIPEC may be an effective alternative to HIPEC, particularly for fragile and elderly patients. Future studies should investigate whether hyperthermia improves cisplatin delivery and cytotoxicity in tumor-infiltrated peritoneal tissues.
Authors
- Mats Bue (ORCID: https://orcid.org/0000-0001-7215-8323)
- Elisabeth Krogsgaard Petersen (ORCID: https://orcid.org/0000-0002-5164-5197)
- Andrea René Jørgensen (ORCID: https://orcid.org/0000-0001-6334-3164)
- Bo Martin Bibby (ORCID: https://orcid.org/0000-0002-4742-4076)
- Anne Schmedes (ORCID: https://orcid.org/0000-0002-6305-8563)
- Christina Harlev (ORCID: https://orcid.org/0000-0001-7255-9557)
- Maiken Stilling (ORCID: https://orcid.org/0000-0002-4530-2075)
- Lone Kjeld Petersen (ORCID: https://orcid.org/0000-0002-1424-6170)
- Mads Kristian Duborg Mikkelsen (ORCID: https://orcid.org/0009-0005-1688-954X)
Institutions
- University of Southern Denmark (DK)
- Aarhus University (DK)
- Odense University Hospital (DK)
- Aarhus University Hospital (DK)
- Lillebaelt Hospital (DK)
Publication Details
- Journal
- European Journal of Surgical Oncology
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1016/j.ejso.2025.110378
- Citations
- 1
- Primary Topic
- Intraperitoneal and Appendiceal Malignancies
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Aarhus Universitet
- Aarhus Universitetshospital
- A.P. Møller og Hustru Chastine Mc-Kinney Møllers Fond til almene Formaal
- Familien Hede Nielsens Fond