Rottlerin inhibits PKCδ to attenuate pulmonary fibrosis by suppressing NLRC4/ASC-mediated pyroptosis
Our findings reveal that Rottlerin alleviates PF by targeting PKCδ to suppress NLRC4/ASC-mediated pyroptosis and inflammation. This study innovatively focused on the anti-pulmonary fibrosis strategy targeting the PKCδ-NLRC4 axis, revealed an important link in the inflammation-fibrosis transition, provided evidence on Rottlerin's anti-fibrotic effects and identifies a novel therapeutic strategy for PF.
Authors
- Ying Xu (ORCID: https://orcid.org/0000-0001-9570-8666)
- Xunjie Gou (ORCID: https://orcid.org/0000-0003-1963-0451)
- Shuang He
- Sijie Zhang (ORCID: https://orcid.org/0000-0002-7165-076X)
- Yuanyi Wang
- Ge Xu (ORCID: https://orcid.org/0000-0002-5557-3274)
- Zixin Chen (ORCID: https://orcid.org/0000-0002-7288-7830)
- Ting Zhang (ORCID: https://orcid.org/0000-0001-9231-1604)
- Wei Yuan (ORCID: https://orcid.org/0009-0008-1630-2085)
- Dongming Wu (ORCID: https://orcid.org/0000-0002-0665-4422)
Institutions
- Chengdu Medical College (CN)
- First Affiliated Hospital of Chengdu Medical College (CN)
- Xintai People's Hospital (CN)
Publication Details
- Journal
- Phytomedicine
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1016/j.phymed.2025.157154
- Citations
- 1
- Primary Topic
- Inflammasome and immune disorders
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- Chengdu Medical College
- National Natural Science Foundation of China
- Department of Science and Technology of Sichuan Province
- Health Commission of Sichuan Province