Genetic insights into lipid traits and atherosclerosis risk: a Mendelian randomization and polygenic risk score analysis
The study demonstrated a clear causal relationship between lipid traits and AS risk. Higher HDL levels were associated with a reduced risk, while higher LDL, TC, and TG levels increase AS risk. The role of lipid metabolism genes in AS pathogenesis was underscored by PRS analysis.
Authors
- Yongjian Wu (ORCID: https://orcid.org/0009-0002-7803-0237)
- Dejing Feng
- Guannan Niu
- Hongliang Zhang (ORCID: https://orcid.org/0000-0002-6427-1171)
- Zhenyan Zhao
- Hui Sun (ORCID: https://orcid.org/0000-0001-8748-6880)
- Wence Shi (ORCID: https://orcid.org/0000-0002-1800-4566)
- Xiaoyu Long
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Chinese PLA General Hospital (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-08-12
- DOI
- https://doi.org/10.1097/js9.0000000000002869
- Citations
- 2
- Primary Topic
- Atherosclerosis and Cardiovascular Diseases
- Type
- article
- Field-Weighted Citation Impact
- 1.59