Intracranial Hemorrhage in Patients With Stroke After Endovascular Treatment With or Without IV Alteplase
In this individual participant data meta-analysis, compared with EVT alone, IVT plus EVT modestly increased the risk of ICH, notably any parenchymal hematoma. Although ICH was associated with worse functional outcomes, this effect may be offset by IVT's benefit in final successful reperfusion and early reperfusion.
Authors
- Simon Jung (ORCID: https://orcid.org/0000-0002-8288-6102)
- Pengfei Xing (ORCID: https://orcid.org/0000-0002-2663-1092)
- Urs Fischer (ORCID: https://orcid.org/0000-0003-0521-4051)
- Andrew Bivard (ORCID: https://orcid.org/0000-0001-7762-5832)
- Jiacheng Huang (ORCID: https://orcid.org/0000-0002-6962-7253)
- Jonathan M. Coutinho (ORCID: https://orcid.org/0000-0002-8284-982X)
- Qi Fang (ORCID: https://orcid.org/0000-0002-9762-2687)
- Hong Bo (ORCID: https://orcid.org/0000-0003-1301-288X)
- Ryuzaburo Kanazawa (ORCID: https://orcid.org/0000-0001-9944-3458)
- Yuji Matsumaru (ORCID: https://orcid.org/0000-0002-4827-8410)
- Bart J. Emmer (ORCID: https://orcid.org/0000-0001-8462-4037)
- Wenjie Zi (ORCID: https://orcid.org/0000-0001-6323-2659)
- Natalie E. LeCouffe (ORCID: https://orcid.org/0000-0002-6668-8755)
- Bernard Yan (ORCID: https://orcid.org/0000-0001-8802-9606)
- Jan Gralla (ORCID: https://orcid.org/0000-0003-1953-9033)
- Johannes Kaesmacher (ORCID: https://orcid.org/0000-0002-9177-2289)
- Geert J. Lycklama
- David S. Liebeskind (ORCID: https://orcid.org/0000-0002-5109-8736)
- Keigo Shigeta (ORCID: https://orcid.org/0000-0003-4300-4231)
- Yuki Kamiya (ORCID: https://orcid.org/0000-0003-3528-6953)
- Jeannette Hofmeijer (ORCID: https://orcid.org/0000-0002-7593-5674)
- Charles B.L.M. Majoie (ORCID: https://orcid.org/0000-0002-7600-9568)
- Daniel Strbian (ORCID: https://orcid.org/0000-0001-9095-2344)
- Kilian M. Treurniet (ORCID: https://orcid.org/0000-0003-3227-3620)
- Seiji Okubo (ORCID: https://orcid.org/0000-0003-0789-242X)
- Lei Zhang (ORCID: https://orcid.org/0000-0003-3439-8611)
- Geoffrey Alan Donnan (ORCID: https://orcid.org/0000-0001-6324-3403)
- Huy‐Thang Nguyen
- Masafumi Morimoto (ORCID: https://orcid.org/0000-0002-4390-2472)
- Qingwu Yang (ORCID: https://orcid.org/0000-0002-2596-2631)
- Xiaofei Ye (ORCID: https://orcid.org/0000-0003-3692-1285)
- Diederik W.J. Dippel (ORCID: https://orcid.org/0000-0002-9234-3515)
- Toshiaki Otsuka (ORCID: https://orcid.org/0009-0004-7994-7594)
- Jiaxing Song (ORCID: https://orcid.org/0000-0002-1945-2360)
- Henry Ma (ORCID: https://orcid.org/0000-0002-0510-8059)
- Liyong Zhang (ORCID: https://orcid.org/0000-0003-1817-4511)
- Steven Bush (ORCID: https://orcid.org/0000-0001-7682-3300)
- Fengli Li
- Peter Mitchell (ORCID: https://orcid.org/0000-0002-8337-7529)
- Yu Zhou (ORCID: https://orcid.org/0000-0002-8095-1257)
- Ya Peng (ORCID: https://orcid.org/0000-0002-2761-4374)
- Wenhuo Chen (ORCID: https://orcid.org/0000-0002-7031-8917)
- Chrysanthi Papagiannaki (ORCID: https://orcid.org/0000-0002-9473-9644)
- Bruce C.V. Campbell (ORCID: https://orcid.org/0000-0003-3632-9433)
- Xiaochuan Huo (ORCID: https://orcid.org/0000-0003-1264-5132)
- Fabiano Cavalcante (ORCID: https://orcid.org/0000-0003-2619-7182)
- Raul G. Nogueira (ORCID: https://orcid.org/0000-0003-4532-153X)
- Igor Sibon (ORCID: https://orcid.org/0000-0002-1171-4215)
- Masataka Takeuchi (ORCID: https://orcid.org/0000-0003-1820-1786)
- Solène de Gaalon (ORCID: https://orcid.org/0000-0003-3989-9589)
- Anouk van Norden
- Romain Bourcier (ORCID: https://orcid.org/0000-0002-6506-4019)
- Hongjian Shen (ORCID: https://orcid.org/0000-0002-4439-9506)
- Yvo B.W.E.M. Roos (ORCID: https://orcid.org/0000-0001-9205-5882)
- Christophe Cognard (ORCID: https://orcid.org/0000-0003-4287-2627)
- Pengfei Yang (ORCID: https://orcid.org/0000-0002-0857-2383)
- Roman Rohner (ORCID: https://orcid.org/0009-0006-1331-705X)
- Manon Kappelhof (ORCID: https://orcid.org/0000-0001-5250-8955)
- Ping Zhang
- Kentaro Suzuki
- Yong‐Wei Zhang (ORCID: https://orcid.org/0000-0001-7255-1678)
- Guangxian Nan (ORCID: https://orcid.org/0000-0002-4858-9622)
- Yongxin Zhang (ORCID: https://orcid.org/0000-0003-3173-4560)
- Kazumi Kimura
- Shouchun Wang (ORCID: https://orcid.org/0000-0002-0714-4299)
- Zifu Li (ORCID: https://orcid.org/0000-0002-9332-3786)
- Hongxing Han
- Margaux Lefebvre
- Marnat Gaultier
- Mikito Hayakawa (ORCID: https://orcid.org/0000-0003-3290-4592)
- Stephen Davis
- Aad van der Lugt
- Vu Dang Luu
- Vincent Costalat
- Yohei Takayama
- Chenghua Xu (ORCID: https://orcid.org/0000-0002-4948-6844)
- Jianmin Liu
Institutions
- University of Bern (CH)
- The Royal Melbourne Hospital (AU)
- University of Tsukuba (JP)
- University of Shanghai for Science and Technology (CN)
- The University of Melbourne (AU)
- Second Military Medical University (CN)
- Leiden University Medical Center (NL)
- Helsinki University Hospital (FI)
- University Hospital of Bern (CH)
- Medisch Centrum Haaglanden (NL)
- Amsterdam Neuroscience (NL)
- Healthcentric Advisors (US)
- Changhai Hospital (CN)
- Xinqiao Hospital (CN)
- Amsterdam University Medical Centers (NL)
- Nippon Medical School (JP)
- University of Amsterdam (NL)
Publication Details
- Journal
- JAMA Neurology
- Published
- 2025-08-11
- DOI
- https://doi.org/10.1001/jamaneurol.2025.2610
- Citations
- 8
- Primary Topic
- Acute Ischemic Stroke Management
- Type
- article
- Field-Weighted Citation Impact
- 10.83