An Inflammation‐Associated Control Mechanism of Allergy by Proteolysis of <scp>IgE</scp>
This work reveals new mechanistic insights into the immunobiology of IgE and the action of omalizumab with potential clinical impacts. Indeed, IgE-specific cleavage by inflammation-associated granulocyte proteinases may be an important feedback mechanism to control allergic responses.
Authors
- Rafaela Vaz Sousa Pereira (ORCID: https://orcid.org/0000-0003-3567-5262)
- Erik Martens (ORCID: https://orcid.org/0000-0002-7947-6567)
- Rik Schrijvers (ORCID: https://orcid.org/0000-0002-4261-6220)
- Christine Breynaert (ORCID: https://orcid.org/0000-0002-7368-1068)
- Mieke Gouwy (ORCID: https://orcid.org/0000-0002-4035-4810)
- Estefanía Ugarte-Berzal (ORCID: https://orcid.org/0000-0001-5182-6361)
- Eva Ganseman (ORCID: https://orcid.org/0000-0002-2305-7451)
- Christine Guntermann (ORCID: https://orcid.org/0000-0001-8220-2578)
- Paul Proost (ORCID: https://orcid.org/0000-0002-0133-5545)
- Dries Wets
- Ghislain Opdenakker (ORCID: https://orcid.org/0000-0003-1714-2294)
Institutions
- Novartis (Switzerland) (CH)
- Rega Institute for Medical Research (BE)
- KU Leuven (BE)
Publication Details
- Journal
- Allergy
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1111/all.16622
- Primary Topic
- Mast cells and histamine
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Fonds Wetenschappelijk Onderzoek
- KU Leuven
- Onderzoeksraad, KU Leuven
- Vlaamse regering
- Rega Foundation
- Novartis Pharma