M2 macrophage-derived extracellular vesicles protect against abdominal aortic aneurysm by modulating macrophage polarization through miR221-5p
miR221-5p in M2-EVs plays a critical role in AAA pathophysiology by modulating macrophage polarization through PARP-1/PP-1ɑ/JNK/c-Jun signaling. M2-EVs and miR221-5p represent promising therapeutic options for AAA.
Authors
- Xiangjiu Ding (ORCID: https://orcid.org/0000-0002-0929-7336)
- Keyin Liu (ORCID: https://orcid.org/0000-0002-0532-0930)
- Feng Xu (ORCID: https://orcid.org/0000-0002-9642-6406)
- Yuanyuan Hu (ORCID: https://orcid.org/0000-0001-6788-702X)
- Mingxiang Zhang (ORCID: https://orcid.org/0000-0003-3084-0775)
- Han Liu (ORCID: https://orcid.org/0000-0002-0014-4675)
- Bin Liu (ORCID: https://orcid.org/0000-0003-1569-2604)
- Yang Ma
- Hao Wang (ORCID: https://orcid.org/0000-0003-4493-3147)
- Xiaofang Huang (ORCID: https://orcid.org/0000-0002-5292-0250)
- Siyu Lu (ORCID: https://orcid.org/0000-0002-4735-0425)
- Weidong Qin (ORCID: https://orcid.org/0000-0001-7238-6860)
Institutions
- Qilu University of Technology (CN)
- Shandong University (CN)
- University of Jinan (CN)
- Ministry of Education (BD)
- Shandong Women’s University (CN)
- Qilu Hospital of Shandong University (CN)
Publication Details
- Journal
- Cellular & Molecular Biology Letters
- Published
- 2025-08-10
- DOI
- https://doi.org/10.1186/s11658-025-00768-w
- Citations
- 4
- Primary Topic
- Aortic aneurysm repair treatments
- Type
- article
- Field-Weighted Citation Impact
- 6.07
Funders
- Natural Science Foundation of Shandong Province
- China International Medical Foundation