UBR5 antagonizes DNA damage to enhance the doxorubicin resistance of triple-negative breast cancer by p38 signaling
UBR5 serves as a critical mediator of chemoresistance in TNBC by regulating the DNA damage response through the p38 signaling pathway. Targeting UBR5 or p38 signaling presents a promising therapeutic approach to overcome treatment resistance.
Authors
- Hanghao Zhang
- Xinyu Shao (ORCID: https://orcid.org/0000-0001-9608-455X)
- Shuai Peng (ORCID: https://orcid.org/0000-0002-8064-920X)
- Xueping Feng
- Xiaomin Wang (ORCID: https://orcid.org/0000-0003-1274-224X)
- Jian Pang
- Liqiu Liao
- Shouman Wang
Institutions
- Central South University (CN)
- Kunming Medical University (CN)
- Hunan Cancer Hospital (CN)
- Second Hospital of Tianjin Medical University (CN)
- Second Xiangya Hospital of Central South University (CN)
- Xiangya Hospital Central South University (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- International Journal of Surgery
- Published
- 2025-08-08
- DOI
- https://doi.org/10.1097/js9.0000000000003061
- Primary Topic
- Ubiquitin and proteasome pathways
- Type
- article
- Field-Weighted Citation Impact
- 0.00