The Hypercoagulable State: A Study of Clot Waveform Analysis, Thrombin Generation, and Clot Scanning Electron Microscopy
We have shown that similar to the TG assay, CWA can detect a hypercoagulable state in patients at increased risk of clotting. Furthermore, we identified differences of in vitro clot texture by SEM that may provide further insight into the underlying pathology. Even though CWA is currently considered a research tool, it might one day become a clinically accepted test and provide value-added information to PT or aPTT testing at minimal computational costs.
Authors
- Maria Ruberto (ORCID: https://orcid.org/0000-0001-9491-1734)
- Terenzio Congiu
- Gavino Faa
- Doris Barcellona (ORCID: https://orcid.org/0000-0002-0823-3357)
- Dimitrios Marco Ntoukas
- Francesco Marongiu (ORCID: https://orcid.org/0000-0001-7277-2868)
- Luigi Barberini (ORCID: https://orcid.org/0000-0002-3815-0392)
- Carmen Porcu
- Maria Vittoria Conti (ORCID: https://orcid.org/0000-0002-8120-7091)
- Silvia Marongiu
Institutions
- University of Cagliari (IT)
- Nuovo Ospedale San Giovanni di Dio (IT)
- Regione Puglia (IT)
- Presidio Ospedaliero (IT)
- Azienda Ospedaliero-Universitaria Cagliari (IT)
- Fondazione Centro Marino Internazionale (IT)
- Azienda Ospedaliera Universitaria Pisana (IT)
Publication Details
- Journal
- Archives of Pathology & Laboratory Medicine
- Published
- 2025-08-11
- DOI
- https://doi.org/10.5858/arpa.2024-0298-oa
- Primary Topic
- Heparin-Induced Thrombocytopenia and Thrombosis
- Type
- article
- Field-Weighted Citation Impact
- 0.00