Trimethylamine N‐Oxide Mitigates Perioperative Neurocognitive Disorders via <scp>ANXA1</scp> Nuclear Translocation and <scp>M2</scp> Microglial Polarization in the Hippocampus
Physiological concentrations of TMAO confer neuroprotection by augmenting ANXA1-mediated resolution of neuroinflammation, supporting its therapeutic potential for preventing PND.
Authors
- Ailin Luo (ORCID: https://orcid.org/0000-0001-8826-5588)
- Xuan Wang (ORCID: https://orcid.org/0000-0002-6588-2951)
- Xing Li (ORCID: https://orcid.org/0000-0002-6569-8935)
- Shiyong Li (ORCID: https://orcid.org/0000-0001-7442-1826)
- Li Luo (ORCID: https://orcid.org/0000-0002-3503-9998)
- Qian Xia (ORCID: https://orcid.org/0000-0001-9110-286X)
- Mengxin Que
- Gaofeng Zhan
Institutions
- Tongji Hospital (CN)
- Huazhong University of Science and Technology (CN)
Publication Details
- Journal
- CNS Neuroscience & Therapeutics
- Published
- 2025-08-01
- DOI
- https://doi.org/10.1111/cns.70558
- Citations
- 1
- Primary Topic
- S100 Proteins and Annexins
- Type
- article
- Field-Weighted Citation Impact
- 0.81
Funders
- National Natural Science Foundation of China
- Tongji University